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Sample text

The evoked responses obtained at the NTS and the contralateral RF in the experiments using the "transected preparation" were similar to those 31 SLEEP-WAKING FEEDBACK CIRCUIT obtained in the "decerebellate intact preparation" in regard to both magnitude and time. , the magnitude of the contralateral MRF evoked response was approximately one-fifth (1/5), of that obtained in the other two preparations. ) between these two structures. The time displacement between these two responses was almost indistinguishable for the other two surgical preparations used in these experiments.

To insure that the information flow depended upon a transmission channel through the NTS in the split preparation, a local anesthetic was applied topically at the site of the NTS. As a result both the evoked response at the NTS and the contralateral RF were significantly reduced, providing verification of the postulates posed at the onset. Discussion Bonvallet and Bloch (4) and Bonvallet and Allen (3), on the basis of their experiments suggested a feedback circuit between the midbrain RF and the region of the NTS.

Llatol" SIMULATED EKG II!! I!!!! III11I1L1lUlm / - .. J TO SIMULATOR Figure 6. R-R period (heart rate) response to combined and simultaneous sympathetic and parasympathetic stimulation in the dog (upper portion of the illustration) and simulated response curve (lower portion of the illustration). References 1. J. " Am. , 30: 747, 1961. 44 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. J. K. CYWINSKI, W. J. WAJSZCZUK, AND A. C. K. " Br. Med. , 22:243, 1966. " Anesthesiology, 29:670, 1968.

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