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Download 50 studies every neurologist should know by David Y. Hwang PDF

By David Y. Hwang

50 experiences each Neurologist should still Know provides key experiences that form the present scientific perform of neurology. All neurologic subspecialties are coated, with a distinct emphasis on neurocritical care and vascular neurology. for every examine, a concise precis is gifted with an emphasis at the effects and boundaries of the research, and its implications for perform. An illustrative scientific case concludes each one evaluate, by way of short details on different correct reviews. this can be the 1st publication of its style to provide a suite of the main influential medical trials in neurology which are certain sufficient for use on rounds, yet nonetheless simply digestible. it's a must-read for future health care pros and somebody who desires to research extra in regards to the information in the back of scientific practice.

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2011;7(3):263–​269. In 1998 NINCDS was renamed the National Institute of Neurological Disorders and Stroke (NINDS)—​its current name. 3. Folstein MF, Folstein SE, McHugh PR. ” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–​198. 4.  318. Contrast Reisberg B, Doody R, Stöffler A, et al. Memantine in moderate-​to-​severe Alzheimer’s disease. NEJM. 2003;348(14):1333–​1341. There, patients receiving antiparkinsonian agents, hypnotic or anxiolytic agents, and antipsychotic (neuroleptic) agents were excluded.

Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol. 2011;68(8):991–​998. Obtaining a “pure AD” population may not often be feasible as, even using strict clinical criteria for AD, a proportion of people meeting these may have no AD pathology at autopsy or mixed pathology. Many trials for dementia then end up including patients with heterogeneous pathology. 9. The trial of Reisberg et al. did exclude patients on medications for parkinsonism. Though in our trial the number of patients on these was <20%, this does not preclude a proportion of patients with dementia related to Parkinson disease or dementia with Lewy bodies.

A b Criticisms and Limitations: The results of the trial are restricted to patients with MMSE scores of 5–​14. 8 While using the Ischemic Score to exclude patients with vascular dementia, it may have included patients with non-​AD dementias. 10 A high11 percentage of patients discontinued study participation (fully a fourth of the placebo group, 51/​201; and 30/​203 assigned to receive memantine), which may have introduced inaccuracies in findings. 14 Other Relevant Studies and Information: • A number of trials have since examined the role of memantine in more specific subgroups with dementia.

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