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Additional resources for Autologous Transfusion - From Euphoria to Reason: Clinical Practice Based on scientific knowledge - Nottwil, January 16-17, 2004: Proceedings
A German version of this article is published in Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie (Thieme, Stuttgart). © 2004 S. com/tmh Historical Development of Autologous Direct Re-Transfusion of Wound and Drainage Blood Direct re-transfusion of wound blood is not a new technique. As early as 1874 Highmore  reported a number of cases of heavy postpartum bleeding; including 1 case in which the shed blood was salvaged, defibrinized, warmed, and re-transfused to the patient.
50%) and the low wash volume (less than a single vs. a 4–6-fold bowl volume). Martin and Popovsky  argued that the risk coming along with the transfusion of frHb does not depend on its concentration but rather on its total amount. 8%. However, neither for the concentration nor for the total amount of frHb toxic limits are known . Moreover, the risk after transfusion of wound blood is not as much dependent on the concentration or amount of frHb but rather on that of products of cellular and humoral activation which are not necessarily linked to the extent of hemolysis.
The proponents of ADR, however, claim that unwanted substances are sufficiently removed by a filter system. We assessed three filter systems with regard to handling and effectiveness in patients undergoing total knee replacement . Wound blood was examined before passage of the filter system and after passage of the ADR system. We found that hemoglobin and Hct were low and remained low in the wound blood. The load of activated platelets was not substantially reduced by the filter system. The same applies to free hemoglobin.